期刊
BIOMATERIALS
卷 34, 期 22, 页码 5651-5660出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.03.085
关键词
Magnetic gold nanorods; Photoacoustic microscopy; MRI; Photothermal therapy; Brain tumor
资金
- National Science Council of the Republic of China
- National Department of Health of the Republic of China
- Ministry of Economic Affairs
- Chang Gung Memorial Hospital, National Tsing Hua University [NSC-101-2120-M-182A-002, NSC 100-2218-E-182-001-, NSC101-2321-B-182-015-, NSC101-2221-E-182-002-MY3, NHRI-EX102-10004NI, CMRPG3A0502, CMRPG3B0451, CMRPG3C0351, 102N2024E1, 102N2772E1]
Nanomedicine can provide a multi-functional platform for image-guided diagnosis and treatment of cancer. Although gold nanorods (GNRs) have been developed for photoacoustic (PA) imaging and near infra-red (NIR) photothermal applications, their efficiency has remained limited by low thermal stability. Here we present the synthesis, characterization, and functional evaluation of non-cytotoxic magnetic polymer-modified gold nanorods (MPGNRs), designed to act as dual magnetic resonance imaging (MRI) and PA imaging contrast agents. In addition, their high magnetization allowed MPGNRs to be actively localized and concentrated by targeting with an external magnet. Finally, MPGNRs significantly enhanced the NIR-laser-induced photothermal effect due to their increased thermal stability. MPGNRs thus provide a promising new theranostic platform for cancer diagnosis and treatment by combining dual MR/PA imaging with highly effective targeted photothermal therapy. (C) 2013 Elsevier Ltd. All rights reserved.
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