期刊
BIOMATERIALS
卷 34, 期 8, 页码 1987-1994出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.11.040
关键词
Magnetic targeting; Stem cell; Nanoparticle; Restenosis; Catheter
资金
- Rosetrees Trust
- Engineering and Physical Sciences Research Council (EPSRC)
- British Heart Foundation (BHF)
- Science Foundation Ireland (SFI), Strategic Research Cluster (SRC) [SFI: 09/SRC B1794]
- Engineering and Physical Sciences Research Council [EP/I014667/1] Funding Source: researchfish
- EPSRC [EP/I014667/1] Funding Source: UKRI
Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. Cells labelled with superparamagnetic iron oxide nanoparticles exhibit no negative effects on cell viability, differentiation or secretion patterns. The increase in stem cell retention leads to a reduction in restenosis three weeks after cell delivery. (C) 2012 Elsevier Ltd. All rights reserved.
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