期刊
BIOMATERIALS
卷 34, 期 21, 页码 5218-5225出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.03.058
关键词
Upconverting nanoparticle; Silica nanosphere; Contrast agents; In vivo test; Multi-modality imaging
资金
- National Basic Research Program of China [2011CB935800]
- NSFC [21075118]
Here, we report the covalently conjugation of lanthanide doped NaGdF4:Yb3+, Er3+@NaGdF4 upconverting nanoparticles (UCNPs) on methylphosphonate functionalized silica nanospheres (pSi NPs) for in vivo upconversion luminescence (UCL), T-1-weighted magnetic resonance (MR), and X-ray computed tomography (CT) multi-modality imaging. The nanocomposites (pSi@UCNPs) were synthesized by a facile ligand exchange strategy. The hydrophobic pSi@UCNPs were transferred into aqueous solution by surface coating Pluronic F127. The Pluronic F127 coated pSi@UCNPs (pSi@UCNPs@F127) exhibit excellent stability in biological medium, inappreciable cytotoxicity and negligible organ toxicity. The pSi@UCNPs@F127 also shows brighter UCL, and higher CT/MR enhancements than that of Pluronic F127 coated NaGdF4:Yb3+, Er3+@NaGdF4 UCNP. In detail, the capability of pSi@UCNP5@F127 as high performance contrast agents for in vivo multi-modality (UCL/MR/CT) imaging is evaluated successfully through small-animal experiments. (C) 2013 Elsevier Ltd. All rights reserved.
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