期刊
BIOMATERIALS
卷 34, 期 22, 页码 5722-5735出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.04.012
关键词
Cancer-drug delivery; Linear-dendritic polymer; Drug conjugate; Self-assembly; Nanorods; Camptothecin
资金
- National Natural Science Foundation of China [21090352]
- National Natural Science Foundation [20974096, 21104065]
- National Fund for Distinguished Young Scholars [50888001]
- Program for Changjiang Scholars and Innovative Research Team in the University of China
- U.S. Department of Defense [BC090502]
Elongated micelles have many desirable characteristics for cancer-drug delivery, but they are difficult to obtain since amphiphilic polymers form such nanostructures only within narrow composition ranges depending on their own structures. Herein, we demonstrated a facile fabrication of different nanostructures via drug content-controlled self-assembly of amphiphilic linear-dendritic drug conjugates - using the number of the conjugated hydrophobic drug molecule camptothecin (CPT) to tailor the hydrophobicity of amphiphilic PEG-block-dendritic polylysine-CPT (PEG-xCPT) conjugates and thereby control their self-assembled nanostructures - nanospheres or nanorods of different diameters and lengths. The shape and size of the nanostructures were found to strongly affect their in vitro and in vivo properties, particularly the blood clearance kinetics, biodistribution and tumor targeting. The nanorods with medium lengths (<500 nm) had a much longer blood circulation and faster cellular uptake than the nanospheres or long nanorods. Thus, polymeric nanorods with proper lengths may be ideal nanocarriers capable of uniting the opposite requirements in cancer-drug delivery. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据