期刊
BLOOD COAGULATION & FIBRINOLYSIS
卷 11, 期 -, 页码 S101-S105出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001721-200004001-00019
关键词
factor VIIa; liver failure; disseminated intravascular coagulation (DIC); bleeding; dengue fever
类别
Recombinant activated factor VII (rFVIIa) was given to three children with acute bleeding resulting from liver failure and disseminated intravascular coagulation. Cases I and II (girls aged 3 years and 6 years, respectively) were diagnosed with Dengue hemorrhagic fever and prolonged shock. Case III, a boy aged 9 months, underwent left lobe hepatectomy for a hepatoblastoma, during which 60% of his liver was removed. This case was complicated by myoglobinuria, liver and renal impairment and early disseminated intravascular coagulation. All three patients exhibited active bleeding. Cases I and II received rFVIIa combined with other blood component replacement, while Case III received rFVIIa as the only hemostatic agent. A bolus of 40-180 mu g/kg b.w. was administered followed by 16.5-33 mu g/kg b.w. per h continuous infusion. As a result, bleeding was controlled, the prothrombin time was shortened and FVII clotting activity was significantly increased. In conclusion, rFVIIa has shown some efficacy in controlling acute bleeding in children with liver failure and disseminated intravascular coagulation. Blood Coagul Fibrinolysis 11 (suppl 1):S101-S105 (C) 2000 Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据