期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 45, 期 4, 页码 955-969出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/45/4/311
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Two new Fricke dosimeter gel systems with low diffusion rates have been developed fro 3D radiation dosimetry purposes. Both systems consist of a solution of 20% (by weight) polyvinyl alcohol (PVA) in a 50 mM H2SO4 solution with 0.4 mM ferrous ammonium sulphate and xylenol orange (FX). The difference in the two gels is the way that the gelation process was initiated: either by bringing the temperature to (a) +5 degrees C or (b) -20 degrees C before returning them to room temperature. These gels are termed 'hydrogel' and 'cryogel', respectively. The hydrogel is optically transparent, and can be used with either optical or MRI detection methods for dosimetric imaging. The cryogel is rubbery in texture but opaque, so its internal Fe3+ concentration can only be measured wit MRI. The hydrogel's optical attenuation coefficient is linear (r(2) = 0.99) with dose from 0 to 20 Gy with a sensitivity of 0.106 cm(-1) Gy(-1) (at 543 nm). In terms of MR relaxation rate, the dose response for both the hydrogel and cryogel was linear (r(2) = 0.99) with a sensitivity of 0.020 s(-1) Gy(-1) (at 1.5 T). The Fe3+ diffusion coefficient (at 20 degrees C) was measured to be 0.14 mm(2) h(-1), which is significantly lower than similar preparations reported fro porcine gelatin or agarose. The PVA-FX gel can be stored fro long periods of time before exposure to radiation since the auto- oxidation rate was 10 times less than that of gelatin-Fricke recipes. The new gels developed in this work are a significant improvement on previous Fricke gel systems.
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