期刊
PLANTA MEDICA
卷 66, 期 3, 页码 251-256出版社
GEORG THIEME VERLAG
DOI: 10.1055/s-2000-8562
关键词
Hernandia nymphaeifolia; Hernandiaceae; bark; aporphine alkaloids; lignans; N-(N-methylcarbamoyl)-O-methyl-bulbocapnine; anti-platelet aggregation activity
A new aporphine, N-(N-methylcarbamoyl)-O-methylbulbocapnine (1), together with seven known compounds, (-)-5'-methoxypodorhizol (2), a mixture of beta-sitosterone (3) and stigmasta-4,22-dien-3-one (4), a mixture of 3 beta-hydroxystigmast-5-en-7-one (5) and 3 beta-hydroxystigmasta-5,22-dien-7-one (6), and a mixture of 6 alpha-hydroxystigmast-4-en-3-one (7) and 6 alpha-hydroxystigmasta-4,22-dien-3-one (8), were isolated in continuing studies on the trunk bark of Formosan Hernandia nymphaeifolia. The structures of these compounds were determined through spectral analyses. In addition, the previously reported six alkaloids, laurotetanine, oxohernagine, thalicarpine, reticuline, (+)-vateamine-2'-beta-N-oxide. (+)-hernandaline and six lignans, (+)-epiaschantin, (+)-epimagnolin, (+)-epiyangambin, (-)-hernone, (-)-yatein, (-)-deoxypodophyllotoxin were demonstrated to have anti-platelet aggregation activity.
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