期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 14, 期 3, 页码 249-251出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0924-8579(99)00159-4
关键词
non antibiotic; diclofenac sodium; anti-bacterial action; inhibition of DNA synthesis
Most strains of Gram-positive and Gram-negative bacteria were inhibited by 50-100 mg/l of the anti-inflammatory agent, diclofenac sodium (Dc). In vivo test using 30 or 50 mu g Dc per 20 g mouse (Swiss Albino variety) significantly (P < 0.001) protected the animals when challenged with 50 MLD of a virulent Salmonella typhimurium. The anti-bacterial action of Dc was found to be due to inhibition of DNA synthesis which was demonstrated using 2 mu Ci (H-3) deoxythymidine uptake. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
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