期刊
JOURNAL OF VIROLOGY
卷 74, 期 8, 页码 3517-3524出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.8.3517-3524.2000
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资金
- NEI NIH HHS [R01 EY005093, EY 05093] Funding Source: Medline
The role of B cells and humoral immunity in herpes simplex virus (HSV) ocular infections was studied in immunoglobulin IJ. chain gene-targeted B-cell-deficient mice (mu K/O), At doses of virus well tolerated by immunocompetent mice, heightened susceptibility of mu K/O mice to herpetic encephalitis as well as to herpetic stromal keratitis (HSK) was observed. An explanation was sought for the increased severity of HSK in the mu K/O mice. First, the lack of antibody responses in mu K/O mice resulted in longer viral persistence and dissemination to the corneal stroma, the site of inflammation. Prolonged virus expression in the corneal stroma was suggested to cause bystander activation of Th1-type CD4+ T cells, further contributing to the severity of HSK lesion expression in mu K/O mice, Second, mu K/O mice generated minimal Th2 cytokine responses compared to wild-type mice, Such responses might serve to downregulate the severity of Th1-mediated HSR lesions.
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