期刊
BIOMATERIALS
卷 34, 期 33, 页码 8291-8300出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.07.020
关键词
Whole cell tumor vaccine; Adjuvant; Nanoparticle; Cytokine
资金
- National Basic Research Program of China (973 Program) [2013CB531505]
- National High-Tech Research and Development Program of China (863 Program) [2012AA02A406]
Whole cell tumor vaccine (WCTV), as a potential treatment modality, elicits limited immune responses because of the poor immunogenicity. To address this issue, researchers have attempted to transduce a cytokine adjuvant into tumor cells, but these single-adjuvant WCTVs curtail the high expectations. In present study, we constructed a multi-adjuvant WCTV based on the nanopartides modified with cell penetrating peptide, which could facilitate the transportation of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 2 (IL-2) into tumor cells. After inactivation, as-designed multi-adjuvant WCTV exhibited programmed promotions on DC recruitment, antigen presentation, and T-cell activation. In vivo evaluations demonstrated the satisfactory effects on tumor growth suppression, metastasis inhibition, and recurrence prevention. Therefore, the nanoparticles-based multiadjuvant WCTV may serve as a high-performance treatment for anti-tumor immunotherapy. (C) 2013 Elsevier Ltd. All rights reserved.
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