期刊
BIOMATERIALS
卷 33, 期 6, 页码 1689-1698出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.11.004
关键词
Single walled carbon nanotubes (SWNTs); Doxorubicin (DOX); Polysaccharides; Drug delivery
资金
- National Science Fund for Distinguished Young Scholars [50925310]
- National Science Foundation of China [20874059, 20904030, 21174087]
- High Technology Research and Development Program of China (863 Project) [2009AA03Z329]
- Major Project of Chinese National Programs for Fundamental Research and Development (973 Project) [2009CB930400, 2012CB933803]
- Shanghai Leading Academic Discipline Project [B202]
- EPFL
- Swiss National Science Foundation
- National Centre of Competence in Research (NCCR) in Chemical Biology
Single walled carbon nanotubes (SWNTs) are emerging as promising delivery vehicles for cancer diagnostics and chemotherapies due to their unique properties, including, remarkable cell membrane penetrability, high drug-carrying capacities, pH-dependent therapeutic unloading, prolonged circulating times and intrinsic fluorescent, photothermal, photoacoustic and Raman properties. In this leading opinion paper, we systemically discuss and evaluate the relationship of the biological safety of SWNTs with their physicochemical properties such as their length, purity, agglomeration state, concentration and surface functionalization. Other relevant issues, including the cellular uptake mechanism, biodistribution and metabolism of SWNTs are also reviewed. The design and preparation of SWNT-based drug delivery systems (DDSs) and their pharmacokinetic, cancer targeting and therapeutic properties both in vitro and in vivo are highlighted. Future opportunities and challenges of SWNT-based DDSs are also discussed. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据