期刊
BIOMATERIALS
卷 33, 期 6, 页码 1730-1735出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.11.023
关键词
Polymeric materials; Surface Micropatterning; Cell nucleus; Stem cells
资金
- Chinese Ministry of Science and Technology [2009CB930000, 2011CB606203]
- NSF of China [21034002]
We herein report a material technique to control the shapes of cell nuclei by the design of the microtopography of substrates to which the cells adhere. Poly(D,L-lactide-co-glycolide) (PLGA) micropillars or micropits of a series of height or depth were fabricated, and some surprising self deformation of the nuclei of bone marrow stromal cells (BMSCs) was found in the case of micropillars with a sufficient height. Despite severe nucleus deformation, BMSCs kept the ability of proliferation and differentiation. We further demonstrated that the shapes of cell nuclei could be regulated by the appropriate micropillar patterns. Besides circular and elliptoid shapes, some unusual nucleus shapes of BMSCs have been achieved, such as square, cross, dumbbell, and asymmetric sphere-protrusion. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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