期刊
BIOMATERIALS
卷 33, 期 18, 页码 4646-4652出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.02.030
关键词
Controlled drug release; Drug release; Growth factors; Hydrogel; Polyvinylalcohol; Cellulose
资金
- EPSRC [EP/F035535/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F035535/1] Funding Source: researchfish
Self-assembled hydrogels with extremely high water content (up to 99.5%) and highly tunable mechanical properties were prepared from renewable cellulose derivatives. These hydrogels are easily processed and the simplicity of their preparation, their availability from inexpensive renewable resources, and the tunability of their mechanical properties are distinguishing for important biomedical applications. The protein release characteristics were investigated to determine the effect of both the protein molecular weight and polymer loadings of the hydrogels on the protein release rate. Extremely sustained release of bovine serum albumin is observed over the course of 160 days from supramolecular hydrogels containing only 1.5 wt% polymeric constituents. This sustained release far surpasses the current state of the art for protein release from a hydrogel, highlighting these materials as important potential candidates for sustained therapeutic applications. (C) 2012 Elsevier Ltd. All rights reserved.
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