期刊
BIOMATERIALS
卷 33, 期 34, 页码 8782-8792出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.08.038
关键词
Nanotopography; Tension line; Fibroblast; Wound healing
资金
- National Research Foundation of Korea (NRF) [NRF-2011-220-D00035]
- WCU (World Class University) program [R31-2008-000-10083-0]
- Basic Science Research Program [2010-0027955]
- NRF [2010-0021066, NRF-2010-220-D00014]
- National Research Foundation of Korea [2010-0021066] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We report on the effect of synthetic extracellular matrix (ECM) scaffold in the form of uniformly-spaced nanogrooved surfaces in dermal wound healing. The rate of wound coverage was measured on various nanotopographical densities with vertical or parallel orientation using nanogrooves of 550 nm width with three different gaps of 550, 1100, and 2750 nm (spacing ratio: 1:1, 1:2 and 1:5). Guided by the nanotopographical cues in the absence of growth factors in wound healing process, the cultured NIH-3T3 cells demonstrated distinctly different migration speed, cell division, and ECM production as dictated by the topographical density and orientation, whereas the proliferation rate turned out to be nearly the same. Based on our experimental results, the nanopattern of 1:2 spacing ratio yielded the best wound healing performance in terms of migration speed, which seems similar to the natural organization of collagen fibers. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
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