期刊
BIOMATERIALS
卷 33, 期 21, 页码 5478-5486出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.04.023
关键词
Nuclear targeting; Nanostructured lipid carrier; Photosensitizer; Drug delivery; Photodynamic therapy; Deep-seated tumor
资金
- Korea Ministry of Education, Science and Technology [2011-0028726]
- Seoul Scholarship Foundation
- National Research Foundation of Korea [핵09A3504] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Photodynamic therapy (PDT) has emerged as a treatment for certain malignant-like skin, head and neck, gastrointestinal, and gynecological cancers. The broader acceptance of PDT treatment for large or deep-seated tumors is still hindered, at least in part, by the low photodynamic efficiency of photosensitizers (PS) in the deep-seated tumor environment where the light energy fluency rate is severely attenuated after propagation via skin and/or tissue barriers. In this report, efficient nuclear-targeted intracellular delivery of PS is achieved using an easily fabricated yet entirely biocompatible and inexpensive polysaccharide-functionalized nanoscale lipid carrier, which triggers the intracellular release of photosensitizers inside cancer cells and targets cell nuclear to achieve a significantly enhanced photocytotoxicity. Cancer cells are killed efficiently even under an extremely low light fluency of 1 mW/cm(2) attenuated via an interval meat layer with a thickness of 3 mm. Therefore, this nuclei-targeting system may contribute to the development of a new generation of PS carriers that fight against deep-seated tumors and that exhibit excellent photodynamic efficiency under faint light irradiation. (C) 2012 Elsevier Ltd. All rights reserved.
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