期刊
BIOMATERIALS
卷 33, 期 7, 页码 2215-2222出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.11.069
关键词
Multifunctional nanoparticles; Multimodal imaging; Magnetic tumor targeting; In vivo cancer treatment; Photothermal therapy
资金
- National Basic Research Programs of China (973 Program) [2012CB932600, 2011CB911002]
- National Natural Science Foundation of China [51002100, 51072126]
- Research Grants Council of Hong Kong SAR-CRF [CityU5/CRF/08]
- Innovation Program of Graduate Students in Jiangsu Province [CX10B_036Z]
Theranostics, the combination of diagnostics and therapies, has become a new concept in the battles with various major diseases such as cancer. Herein, we develop multifunctional nanoparticles (MFNPs) with highly integrated functionalities including upconversion luminescence, superparamagnetism, and strong optical absorption in the near-infrared (NIR) region with high photostability. In vivo dual modal optical/magnetic resonance imaging of mice uncovers that by placing a magnet nearby the tumor, MFNPs tend to migrate toward the tumor after intravenous injection and show high tumor accumulation, which is similar to 8 folds higher than that without magnetic targeting. NIR laser irradiation is then applied to the tumors grown on MFNP-injected mice under magnetic tumor-targeting, obtaining an outstanding photothermal therapeutic efficacy with 100% of tumor elimination in a murine breast cancer model. We present here a strategy for multimodal imaging-guided, magnetically targeted physical cancer therapy and highlight the promise of using multifunctional nanostructures for cancer theranostics. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据