期刊
BIOMATERIALS
卷 33, 期 27, 页码 6438-6446出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.05.065
关键词
Silica; Atomistic and Melocular modeling; Synthesis; Targeted nanoprobe; Biocompatibility and pharmacodynamics
资金
- NSFC of China [81071207, 10875178]
- Specialized Research Fund for the Doctoral Program of Higher Education [20110171110023]
- Fundamental Research Funds for the Central Universities [10ykjcll]
- Open Funds of State Key Laboratory of Oncology in South China [HN2011-02]
The feasibility of the gadolinium-doped mesoporous silica nanocomposite Gd2O3@MCM-41 as a safe, effective MRI nanoprobe has been validated in the current investigation systematically from atomistic and molecular modeling to its synthesis and characterization on in vivo MR imaging and biocompatibility. The first-principles calculation indicates that it is nearly impossible for toxic Gd ions to dissociate freely from silica. The biocompatibility studies confirm that the nanocomposite is lack of any potential toxicity: the biodistribution studies reveal a greater accumulation of the nanocomposite in liver, spleen, lung and tumor than in kidney, heart and brain; the excretion studies show that the nanocomposite can be cleared nearly 50% via the hepatobiliary transport mechanism after 1.5 months of injection. A larger water proton relaxivity r(1) and a better T-1-weighted phantom MR imaging capability were detected in the nanocomposite than in the commercially available gadolinium diethylenetriaminepentaacetate. The results demonstrate that the nanocomposite is superior to the commercial counterpart in terms of contrast enhancement with a satisfactory biocompatibility, and it has a high potential to be developed into a safe and effective targeted probe for in vivo molecular imaging of cancer. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.
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