期刊
BIOMATERIALS
卷 33, 期 21, 页码 5394-5405出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.04.025
关键词
Upconversion luminescence; Upconversion nanoparticle; Multi-modality imaging; Rare-earth nanomaterials; Lanthanide nanoparticle
资金
- National Natural Science Funds [20825101]
- National Science Foundation of China [91027004]
- Shanghai Sci. Tech. Comm. [11XD1400200, 1052 nm03400]
- Shanghai Leading Academic Discipline Project [B108]
- CAS/SAFEA
- Shanghai Key Laboratory of Functional Magnetic Resonance Imaging
Multimodality molecular imaging has recently attracted much attention, because it can take advantage of individual imaging modalities by fusing together information from several molecular imaging techniques. Herein, we report a multifunctional lanthanide-based nanoparticle for near-infrared to near-infrared (NIR-to-NIR) upconversion luminescence (UCL), X-ray computed tomography (CT) and T-1-enhanced magnetic resonance (MR) trimodality in-vivo imaging. By careful selection of the lanthanide elements, core shell structured lanthanide-based nanoparticles, NaLuF4:Yb3+,Tm3+@SiO2-GdDTPA nanoparticles (UCNP@SiO2-GcIDTPA) have been designed and synthesized. We also prove that the application of UCNP@SiO2-GdDTPA for NIR-to-NIR UGL, CT and MRI multi-modality in-vivo imaging can be established successfully. In addition, the biological toxicity of UCNP@SiO2-GdDTPA is evaluated by the methyl thiazolyl tetrazolium (MIL) assay and histological analysis of viscera sections. 2012 Elsevier Ltd. All rights reserved.
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