期刊
BIOMATERIALS
卷 33, 期 10, 页码 3013-3024出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.12.042
关键词
Copolymers; Fluorine-fluoride; Micelle; MRI; Drug delivery
资金
- National Natural Science Foundation of China [50973027]
- Specialized Research Fund for the Doctoral Program of Higher Education [20094208110002]
- Hong Kong Research Grants Council (RGC) [CityU 112510]
Magnetite (Fe3O4) loaded polymer micelles (denoted as magnetomicelles) are produced by self-assembly of fluorine-containing amphiphilic poly(HFMA-g-PEGMA) copolymers with oleic acid modified Fe3O4 nanoparticles in an aqueous medium. The oleic acid modified Fe3O4 nanoparticles form small clusters in the poly(HFMA-g-PEGMA) micelles with a mean diameter of 100 nm and the magnetomicelles show high stability in an aqueous medium due to the high hydrophobic fluorine segments in graft copolymers enhance the stability of the micelles. The magnetomicelles also show good cytocompatibility based on the MU cytotoxicity assay and possess paramagnetic properties with saturation magnetization of 17.14 emu/g.Their good stability, cytocompatibility, and paramagnetic properties render the materials attractive in drug delivery and in vivo magnetic resonance imaging (MRI) applications. Controlled release of hydrophobic drug-5-fluorouracil is achieved from the magnetomicelles with a loading efficiency of 20.94 wt%. The magnetomicelles have transverse relaxivity rates (r(2)) of 134.27 mM (1) s (1) and exhibit high efficacy as a negative MRI agent in T-2-weighted imaging. in vivo MRI studies demonstrate that the contrast between liver and spleen is enhanced by the magnetomicelles. These favorable properties suggest clinical use as nanocarriers in drug delivery applications and contrast agents in MRI. (C) 2011 Elsevier Ltd. All rights reserved.
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