期刊
BIOMATERIALS
卷 33, 期 26, 页码 6201-6210出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.05.036
关键词
Lanthanide; Upconversion nanoparticles; Upconversion luminescence imaging; Multimodal imaging; Water-stable
资金
- NSFC [20825101]
- NHTPC [2011AA03A407, 2012CB932403]
- SSTC [11XD1400200, 1052nm03400]
- SLADP [B108]
- [IRT0911]
Multimodal imaging is rapidly becoming an important tool for biomedical applications because it can compensate for the deficiencies of individual imaging modalities. Herein, multifunctional NaLuF4-based upconversion nanoparticles (Lu-UCNPs) were synthesized though a facile one-step microemulsion method under ambient condition. The doping of lanthanide ions (Gd3+, Yb3+ and Er3+/Tm3+) endows the Lu-UCNPs with high T-1-enhancement, bright upconversion luminescence (UCL) emissions, and excellent X-ray absorption coefficient. Moreover, the as-prepared Lu-UCNPs are stable in water for more than six months, due to the protection of sodium glutamate and diethylene triamine pentacetate acid (DTPA) coordinating ligands on the surface. Lu-UCNPs have been successfully applied to the trimodal CT/MR/UCL lymphatic imaging on the modal of small animals. It is worth noting that Lu-UCNPs could be used for imaging even after preserving for over six months. In vitro transmission electron microscope (TEM), methyl thiazolyl tetrazolium (MTT) assay and histological analysis demonstrated that Lu-UCNPs exhibited low toxicity on living systems. Therefore, Lu-UCNPs could be multimodal agents for CT/MR/UCL imaging, and the concept can be served as a platform technology for the next-generation of probes for multimodal imaging. (C) 2012 Elsevier Ltd. All rights reserved.
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