期刊
BIOMATERIALS
卷 33, 期 6, 页码 1884-1893出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.11.026
关键词
Tumor-identifying polypeptide; Cancer chemotherapy; Tumor extracellular pH; Photodynamic therapy
资金
- Catholic University of Korea
- Gyeonggi Regional Research Center (GRRC)
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science, and Technology [2011-0003874, 2011-0004766]
- Fundamental R&D Program for Core Technology of Materials
- Ministry of Knowledge Economy, Republic of Korea
- National Research Foundation of Korea [2009-0063870] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
One of the current challenges in cancer chemotherapy is the ultra-sensitive identification of in vivo tumors. Herein, we report a new class of tumor-identifying polypeptides that can home in on in vivo tumors via an electrostatic charge conversion process occurring in the acidic milieu of a verity of tumors, which can be distinguished from receptor-interacting conventional tumor-homing peptides. We exploit the chemical coupling between polypeptides and therapeutic objects (drugs or particles) to carry out an antitumor study in nude mice, and find a significant increase in the efficiency of polypeptide-tagged objects in tumor uptake and inhibition, which is more significant than any known tumor-homing peptide system thus far developed. (C) 2011 Elsevier Ltd. All rights reserved.
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