Rb function in cell-cycle regulation and apoptosis

Loss of cell-cycle control is a hallmark of neoplastic cells. One regulator of the critical G1 to S-phase transition in the cell cycle is the retinoblastoma tumour suppressor protein Rb, which interacts with the E2F family of cell-cycle transcription factors to repress gene transcription required for this transition. Through its interaction with E2F, ph also regulates genes that control apoptosis. Here we review the roles of ph in regulating the cell cycle and apoptosis and discuss recent results linking these ph functions to chromatin-remodelling enzymes.