期刊
BIOMATERIALS
卷 32, 期 33, 页码 8555-8561出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.07.071
关键词
Photothermal therapy; Chemotherapy; Graphene oxide; Drug delivery; Synergistic effect
资金
- National Natural Science Foundation of China [60778047]
- Natural Science Foundation of Guangdong Province [9251063101000009]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [200805740003]
Graphene has shown great potential both in photothermal therapy and drug delivery. Herein, we developed doxorubicin-loaded PEGylated nanographene oxide (NGO-PEG-DOX) to facilitate combined chemotherapy and photothermal therapy in one system. In this work, we studied the ablation of tumor both in vivo and in vitro by the combination of photothermal therapy and chemotherapy using this functional graphene oxide. The ability of the NGO-PEG-DOX nanoparticle to combine the local specific chemotherapy with external near-infrared (NIR) photothermal therapy significantly improved the therapeutic efficacy of cancer treatment. Compared with chemotherapy or photothermal therapy alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy. Furthermore, lower systematic toxicity of NGO-PEG-DOX than DOX was proved by the pathologic examination of main organs in our toxicity study. (C) 2011 Elsevier Ltd. All rights reserved.
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