期刊
BIOMATERIALS
卷 32, 期 25, 页码 5880-5888出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.04.080
关键词
Aggregation-enhanced fluorescence; Phospholipid-PEG nanomicelles; Bright nanoprobes; In vivo imaging
资金
- National Natural Science Foundation of China [61008052, 60688401]
- Swedish Foundation for Strategic Research (SSF)
- AOARD
- Fundamental Research Funds for the Central Universities
- China Post-doctoral Science Foundation [20090461394]
- National Basic Research Program of China [2007CB714503]
- Innovation Method Fund of China [2008IM040800]
We report polymeric nanomicelles doped with organic fluorophores (StCN, (Z)-2,3-bis[4-(N-4-(diphenylamino)styryl)phenyl]-acrylonitrile), which have the property of aggregation-enhanced fluorescence. The fluorescent nanomicelles have two unique features: (1) They give much brighter fluorescence emission than mono-fluorophores. (2) The nanomicelles with amphiphilic copolymers [e.g., phospholipids-PEG (polyethylene glycol)] make the encapsulated fluorophores more stable in various bio-environments and easy for further conjugation with bio-molecules. After chemical and optical characterization, these fluorescent nanomicelles are utilized as efficient optical probes for in vivo sentinel lymph node (SLN) mapping of mice. The StCN-encapsulated nanomicelles, as well as their bioconjugates with arginine-glycine-aspartic acid (RGD) peptides, are used to target subcutaneously xenografted tumors in mice, and in vivo fluorescence images demonstrate the potential to use PEGylated phospholipid nanomicelles with aggregation-enhanced fluorescence as bright nanoprobes for in vivo diagnosis of tumors. (C) 2011 Elsevier Ltd. All rights reserved.
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