期刊
BIOMATERIALS
卷 32, 期 20, 页码 4604-4608出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.02.064
关键词
Zwitterionic; Degradable; Reduction-sensitive; Renal clearance; Targeting; MRI (magnetic resonance imaging)
资金
- Office of Naval Research [N000140910137]
- National Science Foundation [DMR-1005699]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1005699] Funding Source: National Science Foundation
Multifunctional and degradable nanogels encapsulating both model drug (fluorescently labeled dextran) and imaging reagent (monodisperse Fe(3)O(4) nanoparticles) were developed by polymerizing zwitterionic monomers with a disulfide crosslinker. Results show that the nanogels have a hydrodynamic size of about 110 nm in saline solution and their size remained unchanged for over 6 months. After being conjugated with a targeting ligand, the nanogels showed a significant cellular uptake by human umbilical vein endothelial cells (HUVEC). The nanogels show low macrophage uptake, implying potential low interaction with the innate immune system. Upon entering the reducing intracellular environment, the disulfide bonds were efficiently cleaved, resulting in the spontaneous release of the encapsulated model drug and Fe(3)O(4) nanoparticles. Magnetic resonance imaging (MRI) studies show that the encapsulation of multiple monodisperse Fe(3)O(4) nanoparticles by the nanogels significantly enhanced their MRI performance (R2 relaxivity), while the disassembling of the Fe(3)O(4) nanoparticles due to the nanogels degradation brings their R2 relaxivity back to that of their original monodisperse form. Furthermore, the degradation properties enable the removal of the disassembled nanogels from the body by renal clearance. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据