期刊
BIOMATERIALS
卷 32, 期 36, 页码 9950-9959出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.09.016
关键词
Dendrimer; Interior-functionalized; Non-toxic; Acetylation; NMR
资金
- East China Normal University [77202201]
- Shanghai Education Commission [10SG27]
In this study, dendrimers was synthesized by introducing functional groups into the interior pockets of fully acetylated dendrimers. NMR techniques including COSY and 2D-NOESY revealed the molecular structures of the synthesized dendrimers and the encapsulation of guest molecule such as methotrexate within their interior pockets. The synthesized polymeric nanocarriers showed much lower cytotoxicity on two cell lines than cationic dendrimers, and exhibited better performance than fully acetylated dendrimers in the sustained release of methotrexate. The results provided a new strategy in the design of non-toxic dendrimers with high performance in the delivery of anti-cancer drugs for clinical applications. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据