期刊
CURRENT OPINION IN LIPIDOLOGY
卷 11, 期 2, 页码 117-122出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00041433-200004000-00003
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Cellular cholesterol efflux, by which cholesterol is transported from peripheral cells to HDL acceptor molecules for transport to the liver, is the first step of reverse cholesterol transport. Two genetic disorders, Tangier disease and some cases of familial HDL deficiency, have defects of cellular cholesterol efflux. The recent discovery of mutations in the ABC1 gene, which encodes the cholesterol efflux regulatory protein, in both these disorders establishes cholesterol efflux regulatory protein as a rate-limiting factor in reverse cholesterol transport. Curr Opin Lipidol 11:117-122. (C) 2000 Lippincott Williams & Wilkins.
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