期刊
BIOMATERIALS
卷 32, 期 28, 页码 6839-6849出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.05.074
关键词
Hydrogel; Affinity; Growth factor; Drug delivery; Controlled drug release
资金
- National Science Foundation [CBET 0967512]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1342893] Funding Source: National Science Foundation
Biomaterials for the precise control of protein release are important to the development of new strategies for treating human diseases. This study aimed to fundamentally understand aptamer protein dissociation triggered by complementary oligonucleotides, and to apply this understanding to develop affinity hydrogels for controlled protein release. The results showed that the oligonucleotide tails of the aptamers played a critical role in inducing intermolecular hybridization and triggering aptamer protein dissociation. In addition, the attachment of the oligonucleotide tails to the aptamers and the increase of hybridizing length could produce a synergistic effect on the dissociation of bound proteins from their aptamers. More importantly, pegylated complementary oligonucleotides could successfully trigger protein release from the aptamer-functionalized hydrogels at multiple time points. Based on these results, it is believed that aptamer-functionalized hydrogels and complementary oligonucleotides hold great potential of controlling the release of protein drugs to treat human diseases. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据