期刊
BIOMATERIALS
卷 32, 期 32, 页码 8161-8171出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.07.045
关键词
Photopolymerization; Hyaluronic acid; Hydrogel; Simvastatin; Bone tissue regeneration
资金
- Korea Science & Engineering Foundation [20100002088]
- Pioneer Research Center [2010-0019346]
- Ministry of Education through the National Research Foundation of Korea [2010-0020791]
- National Research Council of Science & Technology (NST), Republic of Korea [2E2235] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2010-0020786, 2005-2000113, 2010-0019348, 2010-0019346] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We describe in this study the positive influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with simvastatin (SIM). Prior to loading SIM, we first characterized the HA hydrogels for their mechanical properties and swelling ratios. The results from this testing indicated that these two factors improved as the substitution degree of 2-aminoethyl methacrylate (AEMA) increased. MTT and live/dead assays showed that the HA hydrogels have good biocompatibility for use as scaffolds for bone tissue regeneration. Moreover, another KIT assay showed that the photo-cured HA hydrogels III fabricated with 30% AEMA (300 mg) conjugated HA (HA-AEMA iii) loaded with between 0.1 and 1 mg of SIM had a similar cytotoxicity as compared to the HA hydrogel III itself. The sustained release of SIM was observed to occur in the HA hydrogel III loaded with 1 mg of SIM. In vitro and in vivo experiments showed that the HA hydrogel III loaded with 1 mg of SIM had a significant influence on osteogenesis. (C) 2011 Elsevier Ltd. All rights reserved.
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