期刊
BIOMATERIALS
卷 32, 期 35, 页码 9364-9373出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.08.053
关键词
Upconversion nanoparticles; Iron oxide; Composite nanostructures; Multimodal imaging; Drug delivery; Magnetic targeting
资金
- National Natural Science Foundation of China [51002100]
- National 973 Program of China [2011CB911002]
- research fund for the Doctoral Program of Higher Education of China [20103201120020]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Multimodal imaging and imaging-guided therapies have become a new trend in the current development of cancer theranostics. In this work, we encapsulate hydrophobic upconversion nanoparticles (UCNPs) together with iron oxide nanoparticles (IONPs) by using an amphiphilic block copolymer, poly (styrene-block-allyl alcohol) (PS16-b-PAA(10)), via a microemulsion method, obtaining an UC-IO@Polymer multi-functional nanocomposite system. Fluorescent dye and anti-cancer drug molecules can be further loaded inside the UC-IO@Polymer nanocomposite for additional functionalities. Utilizing the Squaraine (SQ) dye loaded nanocomposite (UC-IO@Polymer-SQ), triple-modal upconversion luminescence (UCL)/down-conversion fluorescence (FL)/magnetic resonance (MR) imaging is demonstrated in vitro and in vivo, and also applied for in vivo cancer cell tracking in mice. On the other hand, a chemotherapy drug, doxorubicin, is also loaded into the nanocomposite, forming an UC-IO@Polymer-DOX complex, which enables novel imaging-guided and magnetic targeted drug delivery. Our work provides a method to fabricate a nanocomposite system with highly integrated functionalities for multimodal biomedical imaging and cancer therapy. (C) 2011 Elsevier Ltd. All rights reserved.
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