期刊
BIOMATERIALS
卷 32, 期 5, 页码 1311-1316出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.10.010
关键词
Biocompatibility; Cell encapsulation; Hydrogel; Microsphere; Nanoparticle
资金
- NSF [DMR-1006546]
- Harvard MRSEC [DMR-0820484]
- German Research Foundation (DFG) [SFB 765]
- German Federal Ministry of Education and Research
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [820484] Funding Source: National Science Foundation
We report the preparation of polyglycerol particles on different length scales by extending the size of hyperbranched polyglycerols (3 nm) to nanogels (32 nm) and microgels (140 and 220 mu m). We use miniemulsion templating for the preparation of nanogels and microfluidic templating for the preparation of microgels, which we obtain through a free-radical polymerization of hyperbranched polyglycerol decaacrylate and polyethylene glycol-diacrylate. The use of mild polymerization conditions allows yeast cells to be encapsulated into the resultant microgels with cell viabilities of approximately 30%. (C) 2010 Elsevier Ltd. All rights reserved.
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