期刊
JOURNAL OF IMMUNOLOGY
卷 164, 期 7, 页码 3675-3680出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.164.7.3675
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- NIGMS NIH HHS [GM55194, GM44118] Funding Source: Medline
Sepsis induces extensive apoptosis of lymphocytes, which may be responsible for the profound immune suppression of the disorder. Two potential pathways of sepsis-induced lymphocyte apoptosis, Fas and p53, were investigated. Lymphocyte apoptosis was evaluated 20-22 h after sepsis by annexin V or DNA nick-end labeling. Pas receptor-deficient mice had no protection against sepsis-induced apoptosis in thymocytes or splenocytes. p53 knockout mice (p53(-/-)) had complete protection against thymocyte apoptosis but, surprisingly, had no protection in splenocytes. p53(-/-) mice had no improvement in sepsis survival compared with appropriately matched control mice with sepsis, We conclude that both p53-dependent and p53-independent pathways of cell death exist in sepsis, This differential apoptotic response of thymocytes vs splenocytes in p53(-/-) mice suggests that either the cellular response or the death-inducing signal is cell-type specific in sepsis, The fact that p53(-/-) lymphocytes of an identical subtype (CD8(-)CD4(+)) were protected in thymi but not in spleens indicates that cell susceptibility to apoptosis differs depending upon other unidentified factors.
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