期刊
BIOMATERIALS
卷 32, 期 13, 页码 3447-3458出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.01.032
关键词
Magnetic nanoparticle; Photodynamic therapy; Magnetic resonance imaging; Near-infrared fluorescence imaging; Chlorin e6; Gastric cancer
资金
- National Key Basic Research Program [2010CB933901]
- National 863 Hi-tech Project [2007AA022004]
- Important National Science & Technology Specific Projects [2009ZX10004-311]
- National Natural Scientific Fund [20803040]
- Shanghai [1052nm04100]
- New Century Excellent Talent of Ministry of Education of China [NCET-08-0350, 20070248050, 20070248107]
- Shanghai Science and Technology Fund [10XD1406100]
- Shanghai Jiao Tong University
A major challenge in nanotechnology and nanomedicine is to integrate tumor targeting, imaging, and selective therapy functions into a small single nanoparticle (<50 nm). Herein, photosensitizer-conjugated magnetic nanoparticles with similar to 20 nm in diameter were strategically designed and prepared for gastric cancer imaging and therapy. The second generation photosensitizer chlorin e6 (Ce6) was covalently anchored on the surface of magnetic nanoparticles with silane coupling agent. We found that the covalently incorporated Ce6 molecules retained their spectroscopic and functional properties for near-infrared (NIR) fluorescence imaging and photodynamic therapy (PDT), and the core magnetic nanoparticles offered the functions of magnetically guided drug delivery and magnetic resonance imaging (MRI). The as-prepared single particle platform is suitable for simultaneous targeting PDT and in vivo dual-mode NIR fluorescence imaging and MRI of nude mice loaded with gastric cancer or other tumors. (C) 2011 Elsevier Ltd. All rights reserved.
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