期刊
BIOMATERIALS
卷 32, 期 33, 页码 8456-8461出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.07.062
关键词
Hydrogel; Mechanical properties; Crosslinking; Ligament replacement
资金
- Office of Naval Research [N000140910137]
Hydrogels are widely studied as tissue engineering scaffolds, but the biological tissues they are designed to mimic are often complex tissues with non-uniform chemical and mechanical profiles. This work reports a new strategy to create hydrogels composed of a continuous sheet of a single nonfouling but functionalizable material with mechanical and/or chemical functionality gradients. By using different combinations of functionalizable or nonfunctionalizable versions of nonfouling carboxybetaine methacrylate (CBMA) and carboxybetaine dimethacrylate crosslinker (CBMAX), various hydrogels with gradients of crosslinking densities and/or functionalizable groups can be created. In this work, we demonstrate this concept with two nonfouling hydrogels, both with a mechanical gradient: one with uniform functionalizability and the other with a gradient in chemical functionalizability. With this versatile system, hydrogels with built-in gradient profiles of various types can be controlled at will for a given application. (C) 2011 Elsevier Ltd. All rights reserved.
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