期刊
BIOMATERIALS
卷 32, 期 23, 页码 5417-5426出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.04.006
关键词
Nanogel; Folate-targeting; Cisplatin; Ovarian cancer; Drug delivery
资金
- U.S.A. National Institute of Health [CA116590]
- Department of Defense USA MRMC [06108004]
- NIH [RR021937]
Nanogels are comprised of swollen polymer networks and nearly 95% water and can entrap diverse chemical and biological agents for cancer therapy with very high loading capacities. Here we use diblock copolymer poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) to form nanogels with the desired degree of cross-linking. The nanogels are further conjugated to folic acid (FA) and loaded with different types of drugs (cisplatin, doxorubicin). For the first time we demonstrate a tumor-specific delivery and superior anti-tumor effect in vivo of an anti-cancer drug using these polyelectrolyte nanogels decorated with folate-targeting groups. This reinforces the use of nanogels for the therapy of ovarian and other cancers, where folate receptor (FR) is overexpressed. (C) 2011 Published by Elsevier Ltd.
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