期刊
CURRENT OPINION IN CELL BIOLOGY
卷 12, 期 2, 页码 235-243出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(99)00081-2
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The Smad signalling pathway is critical for transmitting transforming growth factor-beta (TGF-beta) superfamily signals from the cell surface to the nucleus. In the nucleus, Smads regulate transcriptional responses by recruiting co-activators and co-repressors to a wide array of DNA-binding partners. Thus, Smads function as transcriptional co-modulators to regulate TGF beta-dependent gene expression.
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