Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation

A series of benzylideneacetophenone derivatives have been synthesized and found to show potent inhibition of the lipid peroxidation (LPO) in rat liver microsomes. All 19 compounds prepared in this series are LPO inhibitors. The highest activity was found in para hydroxy derivatives with two meta tert-butyl substituents. (C) 2000 Editions scientifiques et medicales Elsevier SAS.