期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 25, 期 4, 页码 200-206出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01557-7
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资金
- NIGMS NIH HHS [GM43080] Funding Source: Medline
Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics.
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