期刊
MOLECULAR CELL
卷 5, 期 4, 页码 707-716出版社
CELL PRESS
DOI: 10.1016/S1097-2765(00)80249-X
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资金
- NCI NIH HHS [CA25951] Funding Source: Medline
- NIEHS NIH HHS [ES08823] Funding Source: Medline
Imprinted gene identification in animals has been limited to eutherian mammals, suggesting a significant role for intrauterine fetal development in the evolution of imprinting. We report herein that M6P/IGF2R is not imprinted in monotremes and does not encode for a receptor that binds IGF2. In contrast, M6P/IGF2R is imprinted in a didelphid marsupial, the opossum, but it strikingly lacks the differentially methylated CpG island in intron 2 postulated to be involved in imprint control. Thus, invasive placentation and gestational fetal growth are not required for imprinted genes to evolve. Unless there was convergent evolution of M6P/IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes.
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