期刊
FISHERIES SCIENCE
卷 66, 期 2, 页码 223-231出版社
JAPANESE SOC FISHERIES SCIENCE
DOI: 10.1046/j.1444-2906.2000.00038.x
关键词
goldfish; gonadotropin; mRNA; ovariectomy; sex steroid
类别
In order to elucidate the regulation of gonadotropin (GTH) gene expression by gonadal sex steroids, the effects of ovariectomy and sex steroid administration on pituitary mRNA levels of GTH subunits were examined in goldfish. Ovariectomy caused a marked increase in GTH 1 beta mRNA levels, and steroid hormone replacement (testosterone, T; estradiol-17 beta, E-2; and 11-ketotestosterone, KT) suppressed the elevated levels in sexually early recrudescent and mature females. Pituitary mRNA levels of alpha and GTH 11 beta were not affected by ovariectomy and steroid hormone treatment. When sex steroids (T, E-2, and KT) were administered to sexually immature juvenile fish, GTH 1 beta mRNA levels were suppressed as observed in adult fish. However, GTH 11 beta mRNA levels were observed to increase by sex steroids (T and E-2 but not KT) unlike that observed with adult fish. These results indicate that sex steroids exert an inhibitory effect on GTH Ip mRNA levels from the time goldfish are immature to the time they are mature. However, sex steroids (T and E-2) have a stimulatory effect on GTH 11 beta mRNA levels in juvenile goldfish and the effect becomes less pronounced when they become adult.
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