期刊
SEMINARS IN IMMUNOLOGY
卷 12, 期 2, 页码 109-119出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/smim.2000.0213
关键词
KIR; CD94; HLA-E; HLA-G; MICA; NK cell; T lymphocyte
类别
NK cells recognize several HLA class IZ, molecules employing both immunoglobulin-like (Ig-like) and C-type lectin receptors. The CD95/NKG2 and NKG2D lectin-like molecules, respectively, interact with HLA-E and MICA; CD94/NKG2A functions as an inhibitory receptor, while CD94/NKG2C and NKG2D trigger NK cell activity. HLA-E predominantly presents nonamers from the lender sequences of other class I molecules; a peptide derived from HLA-GI constitutes the highest affinity ligand for both CD94/NKG2 receptors. Members of the Ig-like transcript (ILT) or leucocyte Ig-like receptor (LIR) family (ILT2 or LIR-1 and ILT4 or LIR-2), expressed by other leucocyte lineages, interact with a broad spectrum of HLA class In molecules and HLA-G1. Among Ig-like KIRs, the KIR2DL4 (p49) receptor has been shown to specifically recognize HLA-GI; this molecule displays an unusual hybrid structure, sharing features with inhibitory and triggering KIRs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据