期刊
SEMINARS IN IMMUNOLOGY
卷 12, 期 2, 页码 101-108出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/smim.2000.0212
关键词
HLA class I; HLA-G; inhibitory receptor; major histocompatibility complex; natural killer
类别
Natural killer (NK) cell activation is regulated by a combination of positive and negative signals coming from repertoires of activating and inhibitory receptors expressed on the surface of each NK cell. Receptors specific for major histocompatibility complex (MHC) class I molecules on ta-get cells inhibit NK effector functions such as cytotoxicity and cytokine production. As reviewed here, the killer cell Ig-like receptor (KIR) family on, human NK cells includes receptors with activating as well as inhibitory potential, receptors that have no known ligand, and inhibitory receptors with well-defined specificities Sor MHC class I such as HLA-B and HLA-C.
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