期刊
BIOMATERIALS
卷 31, 期 18, 页码 4829-4834出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.02.074
关键词
Quantum dots; Cytotoxicity; Nanomaterials
资金
- New Century Excellent Talents in University [NCET-06-0445]
- National Science Foundation of China [10775169, 10905086, 10975179, 90913014, 30870588]
- MOST973 program [2006CB705605, 2006CB933000, 2007CB936000]
- ministry of Health [2009ZX10004-301]
- Shanghai Municipal Commission for Science and Technology [0952nm04600, 08ZR1422700, 08JC1422600]
A systematic study was carried out on the relationship between the cytotoxicity of quantum dots (QDs) and free cadmium ions using CdCl2 solution with known amounts of Cd2+ as the control. We found that the CdTe QDs were more cytotoxic than CdCl2 solutions even when the intracellular Cd2+ concentrations were identical in HEK293 cells treated with them, implying the cytotoxicity of CdTe QDs cannot attributed solely to the toxic effect of free Cd2+. Moreover, we discovered that the cytotoxicity of QDs was based on the concentration of total QDs ingested by cells. Our data clearly showed that specific properties of nanopartices have an obvious influence on their cytotoxicity. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据