期刊
BIOMATERIALS
卷 31, 期 22, 页码 5849-5854出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.03.077
关键词
Nano particle; Platinum; Biomimetic material; Metal surface treatment; Surface modification; Drug delivery
资金
- Ministry of Education, Culture, Sports, Science and Technology
We have shown that platinum nanoparticle species (nano-Pt) is a superoxide dismutase/catalase mimetic that scavenges superoxide and hydrogen peroxide. In Caenorhabditis elegans, nano-Pt functions as an effective antioxidant that induces an extension in lifespan and strong resistance against excessive oxidative stress. Our study with C. elegans was the first trial to use nano-Pt as a bio-active substance. However, a high concentration of nano-Pt was required for these survival effects, probably due to limited membrane permeability. Here, we show that the conjugation of nano-Pt with an HIV-1 TAT fusion protein C-terminally linked to a peptide with high affinity for platinum improves internalization, eliciting a similar level of antioxidant effects at one hundredth the concentration of unconjugated nano-Pt. This approach is a potential method to facilitate translocation of bio-active nanoparticles into living organisms and could be a model assay for estimate the effects of antioxidant in living organism. (C) 2010 Elsevier Ltd. All rights reserved.
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