期刊
BIOMATERIALS
卷 31, 期 6, 页码 1278-1286出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.11.008
关键词
Thermally responsive material; Microbubble; Cancer ablation; Thermal ablation margin; Intraoperative imaging; Ultrasound
资金
- DOD Breast Cancer Research Program [W81XWH-07-1-0646, W81XWH-09-1-0363]
- Boehringer Ingelheim [RG 502H PLGA]
A heat-sensitive microbubble (HSM) agent, comprising a core of liquid perfluorocarbon (PFC) compound and a shell of biodegradable poly lactic-co-glycolic acid (PLGA), was fabricated using an emulsion evaporation method. Optical microscopic imaging showed that heating the HSM suspension to 55 degrees C activated the HSMs for significant volumetric expansion. After placing a HSM-dispersed agar-agar gel phantom in a 55 degrees C water bath for 10 min, the phantom became ultrasonically hyperechoic due to the HSM expansion. In an ex vivo test, a porcine tissue sample was injected with the HSM suspension and placed in a 55 degrees C water bath for 10 min. US imaging clearly identified the hyperechoic regions resulted from the HSM activation. The hyperechoic regions in the tissue sample kept a strong US contrast for more than 1 h. In a simulated ablation process, a HSM-dispersed agar-agar gel phantom was ablated by a cylindrical heating element. US imaging accurately estimated the ablation margin propagation while thermographic imaging underestimated the ablation margin. Our experiments demonstrated that the HSM agent could be used as a novel contrast agent for intraoperative assessment of ablation margins in cancer thermal ablation therapies. (C) 2009 Elsevier Ltd. All rights reserved.
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