期刊
BIOMATERIALS
卷 30, 期 1, 页码 89-93出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.09.020
关键词
Catheter; Hospital acquired infection; Polymer; Nanoparticle; Light-activated antimicrobial
资金
- BBSRC [BB/E012310/1]
- EPSRC [EP/E026141/1]
- Royal Society/Wolfson
- Biotechnology and Biological Sciences Research Council [BB/E012310/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/E026141/1] Funding Source: researchfish
We report the formation of polysiloxane polymers containing embedded methylene blue and gold nanoparticles incorporated by a swell-encapsulation-shrink method. These polymers show significant antimicrobial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli with up to a 3.5 log(10) reduction in the viable count when exposed for 5 min to light from a low power 660 nM laser. The bacterial kill is due to the light-induced production of singlet oxygen and other reactive oxygen species by the methylene blue. Interestingly, the presence of 2 nM gold nanoparticles significantly enhanced the ability of the methylene blue to kill bacteria. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据