期刊
BIOMATERIALS
卷 30, 期 8, 页码 1512-1523出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.12.001
关键词
Magnesium; Calcium phosphate coating; Bioactivity; Biocompatility; Bone; in vitro rest
资金
- Institute of Metal Research (IMR)
- Chinese Academy of Sciences (CAS)
- Shenyang Science and Technology Institute [1062109-1-00]
- Heilongjiang Province Natural Funding [E2007-18]
Magnesium has shown potential application as a bio-absorbable biomaterial, Such as for bone screws and plates. In order to improve the Surface bioactivity. a calcium phosphate was coated oil a magnesium alloy by a phosphating process (Ca-P coating). The Surface characterization showed that a porous and netlike CaGPO(4)center dot 2H(2)O layer with small amounts of Mg-21 and Zn-21 was formed oil the surface of the Mg alloy. Cells L929 showed significantly good adherence and significantly high growth rate and proliferation characteristics oil the Ca-P coated magnesium alloy (p < 0.05) in in-vitro cell experiments, demonstrating that the Surface cytocompatibility of magnesium was significantly improved by the Ca-P coating. In vivo implantations of the Ca-P coated and the naked alloy rods were carried Out to investigate the bone response at the early stage. Both routine pathological examination and immunohistochemical analysis demonstrated that the Ca-P coating provided magnesium with a significantly good Surface bioactivity (p < 0.05) and promoted early bone growth at the implant/bone interface. It Was suggested that the Ca-P coating might be all effective method to improve the surface bioactivity of magnesium alloy. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据