期刊
BIOMATERIALS
卷 30, 期 22, 页码 3771-3779出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.03.044
关键词
Antimicrobial; Silver; Controlled drug release; Nanoparticle; Cystic fibrosis
资金
- University of Akron (Firestone Fellowship)
- Washington University School of Medicine
- National Institute of Allergies and Infectious Diseases [1 R01 A106785601]
- National Institute of General Medical Sciences [5 R01 GM086895-02]
- National Science Foundation [CHE-8808587, CHE-9977144, CHE-0116041]
- Ohio Board of Regents
The pressing need to treat multi-drug resistant bacteria in the chronically infected lungs of cystic fibrosis (CF) patients has given rise to novel nebulized antimicrobials. We have synthesized a silver-carbene complex (SCC10) active against a variety of bacterial strains associated with CIF and chronic lung infections. Our studies have demonstrated that SCC10-loaded into L-tyrosine polyphosphate nanoparticles (LTP NPs) exhibits excellent antimicrobial activity in vitro and in vivo against the CF relevant bacteria Pseudomonas aeruginosa. Encapsulation of SCC10 in LTP NPs provides sustained release of the antimicrobial over the course of several days translating into efficacious results in vivo with only two administered doses over a 72 h period. (C) 2009 Elsevier Ltd. All rights reserved.
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