期刊
BIOMATERIALS
卷 30, 期 10, 页码 1881-1889出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.12.042
关键词
Mesoporous structure; Magnetic nanoparticle; Biomedicine; Drug delivery; Superparamagnetic
资金
- National Natural Science Foundation of China [20675076, 20820102037]
- 973 Project [2007CB714500, 2009CB930100]
In this contribution, we report a facile, gram-scale, low-cost route to prepare monodisperse superparamagnetic single-crystal magnetite NPs with mesoporous structure (MSSMN) via a very simple solvothermal method. The formation mechanism of MSSMN is also discussed and we think that Ostwald ripening probably plays an important role in this synthesis process. It is also interestingly found that the size and morphology of mesoporous Fe3O4 NPs can be easily controlled by changing the amount of NaOH and 1,2-ethylenediamine (ETH). Most importantly, the MSSMN can be used as an effective drug delivery carrier. A typical anticancer drug, doxorubicin (Dox), is used for drug loading, and the release behaviors of Dox in two different pH solutions are studied. The results indicate that the MSSMN has a high drug loading capacity and favorable release property for Dox; thus, it is very promising for the application in drug delivery. (C) 2008 Elsevier Ltd. All rights reserved.
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