期刊
BIOMATERIALS
卷 30, 期 6, 页码 1080-1088出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.10.046
关键词
Mesoporous wollastonite; Composite scaffold; Hydrophilicity; Bioactivity; Cell attachment and proliferation
资金
- National Science Foundation for Distinguished Young Scholars of China [20425621]
- Major State Basic Research Program of China [2005CCA01000]
- Shanghai Pujiang Program (2008)
- hanghai Leading Academic Discipline Project (13502)
- Nano special program of Science and Technology Development of Shanghai [0852nm02700]
- National Research Foundation of Korea [핵06B3604] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A well-defined mesoporous structure of wollastonite with high specific surface area was synthesized using surfactant P123 (triblock copolymer) as template, and its composite scaffolds with poly(E-caprolactone) (PCL) were fabricated by a simple method of solvent casting-particulate leaching. The measurements of the water contact angles suggest that the incorporation of either mesoporous wollastonite (m-WS) or conventional wollastonite (c-WS) into PCL could improve the hydrophilicity of the composites, and the former was more effective than the later. The bioactivity of the composite scaffold was evaluated by soaking the scaffolds in a simulated body fluid (SBF) and the results show that the m-WS/PCL composite (m-WPC) scaffolds can induce a dense and continuous layer of apatite after soaking for 1 week, as compared with the scattered and discrete apatite particles on the c-WS/PCL composite (c-WPC) scaffolds. The m-WPC had a significantly enhanced apatite-forming bioactivity compared with the c-WPC owing to the high specific surface area and pore volume of m-WS. In addition, attachment and proliferation of MG(63) cells on m-WPC scaffolds were significantly higher than that of c-WPC, revealing that m-WPC scaffolds had excellent biocompatibility. Such improved properties of m-WPC should be helpful for developing new biomaterials and may have potential use in hard tissue repair. 2008 (C) Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据